A focused, working scientific meeting at the forefront of antibody-drug conjugates and bi-specific medicines.
Over three days, participants from leading academic centers, community practices, and life science companies will review emerging clinical and translational data, discuss unmet needs in solid tumors and hematologic malignancies, and explore strategies to design, execute, and implement next-generation antibody-based trials and therapies in routine practice.
UCLA Health
MD, MPH
Professor of Medicine & Director of Translational Research Integration
Stanford Cancer Institute
MD
Suzy Yuan-Huey Hung Endowed Professor of Medical Oncology & Associate Director of Clinical Research

UCLA Health
Aditya Bardia
MD, MPH
Professor of Medicine and Director of Translational Research Integration

Stanford Cancer Institute
Mark Pegram
MD
Suzy Yuan-Huey Hung Endowed Professor of Medical Oncology & Associate Director of Clinical Research

UCLA Medical Center
Dennis Slamon
MD, PhD
Professor; Executive Vice Chair for Research; Director, Clinical/Translational Research

UCLA Health
Gottfried Konecny
MD
Associate Professor & Lead Clinician, Gynecologic Oncology

UCLA Health
Jonathan Goldman
MD
Professor of Medicine & Associate Director of Early Drug Development, UCLA

UCLA Health
Alexandra Drakaki
MD, PhD
Associate Professor of Hematology/Oncology & Urology

Mass General Hospital
Oladapo Yeku
MD, PhD, FACP, FASCO
Associate Professor & Director of Translational Research, Gynecologic Oncology Program

UCLA Health
Sarah Larson
MD
Associate Professor, Department of Medicine, Hematology/Oncology

Cleveland Clinic
Alex Adjei
MD, PhD
Chair, Taussig Cancer Institute & Deputy Director, Case Comprehensive Cancer Center

MD Anderson
Funda Meric-Bernstam
MD
Nellie B. Connally Chair in Breast Cancer & Chair, Investigational Cancer Therapeutics

Stanford Health Care
Vivek Subbiah
MD
Professor of Medicine and Executive Medical Director, Novel Therapies & Clinical Trial Network

MIT & Harvard Medical School
Shiladitya Sengupta
PhD
Associate Professor

City of Hope
Ravi Salgia
MD, PhD
Professor and Chair, Arthur & Rosalie Kaplan Endowed Chair in Medical Oncology

City of Hope
Tanya Dorff
MD, FASCO
Division Chief, Genitourinary Disease Program & Professor of Medical Oncology

UCI Health
Nataliya Mar
MD
Assistant Professor, Division of Hematology/Oncology, Department of Medicine

UCLA Health
Zev Wainberg
MD, MSc
Professor of Medicine & Co-Director, GI Oncology Program

UT Southwestern
Isaac Chan
MD, PhD
Assistant Professor of Internal Medicine

Dana Farber
Ana Garrido-Castro
MD
Director, Triple-Negative Breast Cancer Research & Assistant Professor of Medicine
Times and speakers are subject to change.
Welcome & Summit Orientation
9:00 AM – 9:15 AM Aditya Bardia & Mark PegramADC Target Discovery & Validation: From Biology to Development Readiness
9:15 AM – 10:00 AM Dennis Slamon - UCLAEmerging Targets: The Next Wave of Antibody-Based Oncology
10:30 AM – 11:00 AM Vivek Subbiah - StanfordPayload & Linker Engineering: Stability, Delivery & Therapeutic Index
11:00 AM – 11:30 AM Shiladitya Sengupta - MITPanel: Designing the Next Wave of Antibody-Based Therapies
11:30 AM – 12:00 PMBuilding the Next Generation of ADCs
1:30 PM – 2:00 PM Elaine Hurt - AstraZenecaTROP2: Sequencing, Combinations & Development Strategy
2:00 PM – 2:30 PM Shweta Jain - MerckFolate Receptor: Patient Selection & Therapeutic Strategy
2:30 PM – 3:00 PM Gottfried Konecny - UCLADLL3: Re-Targeting an Established Antigen with New Platforms
3:30 PM – 4:00 PM Jonathan Goldman - UCLAPanel: Target Selection, Differentiation & Development Strategy
4:00 PM – 4:30 PMTimes and speakers are subject to change.
Adjacent Modalities: Radioligands & Targeted Payload Delivery
8:30 AM – 9:00 AM Tanya Dorff - City of HopeB7-H3: Translational Rationale & Clinical Opportunity
9:00 AM – 9:30 AM Nataliya Mar - UCIPanel: Expanding the Antibody-Based Therapeutic Toolkit
9:30 AM – 10:45 AMLymphoma: ADC & Multi-Specific Strategies - Practice, Pipeline & Pitfalls
11:00 AM – 11:30 AM Sarah Larson - UCLAMultiple Myeloma: ADCs & Bi-Specific Antibodies in Development and Practice
11:30 AM – 12:00 PM Ajai Chari - UCSFGI Cancers: ADC & Bi-Specific Opportunities Across Emerging Targets
1:30 PM – 2:00 PM Zev Wainberg - UCLABladder Cancer: ADC & Bi-Specific Landscape - Targets, Trials & Next Steps
2:00 PM – 2:30 PM Alexandra Drakaki - UCLAProstate Cancer: ADCs, Bi-Specifics & Targeted Antibody Strategies
2:30 PM – 3:00 PM Terence Friedlander - UCSFLung Cancer: ADC & Bi-Specific Landscape - Targets, Trials & Integration
3:30 PM – 4:00 PM Ravi Salgia - City of HopeGynecologic Cancers: ADC & Bi-Specific Opportunities - Patient Selection & Sequencing
4:00 PM – 4:30 PM Oladapo Yeku - MGHBreast Cancer: ADC & Bi-Specific Development Strategy
4:30 PM – 5:00 PM Aditya Bardia - UCLAPanel: Integrating ADCs & Bi-Specifics Across Solid Tumors
5:00 PM – 5:30 PMTimes and speakers are subject to change.
Biliary Cancer: ADC & Bi-Specific Landscape - Targets, Trials & Emerging Strategies
8:45 AM – 9:15 AM Rob Iannone - Jazz PharmaceuticalsPreclinical Modeling of ADC Activity and Rationale Combinations
9:15 AM – 9:45 AM Funda Meric-Bernstam - MD AndersonBiomarkers: Patient Selection, Response Monitoring & Resistance Signals
9:45 AM – 10:15 AM Isaac Chan - UT SouthwesternTherapeutic Resistance: Mechanisms, Biomarkers & Next-Generation Strategies
11:00 AM – 11:30 AM Ana Garrido-Castro - Dana FarberPanel: Biomarkers, Resistance & the Next Development Frontier
11:30 AM – 12:00 PMSummit Synthesis & Next Steps
12:00 PM – 12:15 PM Aditya Bardia & Mark Pegram